Nano-emulsions as vehicles for topical delivery of forskolin
Authors:
- Małgorzata Miastkowska,
- Elżbieta Sikora,
- Elwira Lasoń,
- Maria Jose Garcia-Celma,
- Elvira Escribano-Ferrer,
- Conxita Solans,
- Meritxell Llinas
Abstract
Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25°C. Studies of forskolin in vitro skin permeation from the nano-emulsions and from a triglyceride solution were carried out at 32°C, using Franz-type diffusion cells. A mixture of PBS/ethanol (60/40 v/v) was used as a receptor solution. The highest flux and permeability coefficient was obtained for the system stabilized with Polysorbate 80 (6.91±0.75µg·cm-2·h-1 and 9.21·10-3 ± 1.00·10-3cm·h-1, respectively) but no significant differences were observed with the flux and permeability coefficient value of forskolin dissolved in oil. The obtained results showed that the nano-emulsions developed in this study could be used as effective carriers for topical administration of forskolin.
- Record ID
- CUT830b740ace0945fba167fba1b913f849
- Publication categories
- ;
- Author
- Journal series
- Acta Biochimica Polonica, ISSN 0001-527X, e-ISSN 1734-154X
- Issue year
- 2017
- Vol
- 64
- No
- 4
- Pages
- 713-718
- Other elements of collation
- tab.; wykr.; Bibliografia (na s.) - 717-718; Oznaczenie streszczenia - Streszcz. ang.; Numeracja w czasopiśmie - Vol. 64, No 4
- Keywords in English
- forskolin, nano-emulsions, medium chain triglycerides, in vitro skin permeation
- DOI
- DOI:10.18388/abp.2017_2334 Opening in a new tab
- URL
- http://www.actabp.pl/#File?./html/4_2017/2017_2334.html Opening in a new tab
- Related project
- Politechnika XXI wieku – Program rozwojowy Politechniki Krakowskiej – najwyższej jakości dydaktyka dla przyszłych polskich inżynierów. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 15
- Publication indicators
- = 7
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT830b740ace0945fba167fba1b913f849/
- URN
urn:pkr-prod:CUT830b740ace0945fba167fba1b913f849
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.