In vitro cytotoxicity of hydrogels based on chitosan and modified with gold nanoparticles
Authors:
- Bożena Tyliszczak,
- Anna Drabczyk,
- Sonia Kudłacik-Kramarczyk,
- Katarzyna Bialik-Wąs,
- Agnieszka Sobczak-Kupiec
Abstract
Hydrogels belong to the group of polymers that recently become more and more popular. This is a result of unique properties of the mentioned materials such as biocompatibility, biodegradability as well as a great sorption capacity. Combination of such polymers with gold nanoparticles results in the preparation of innovative materials that can be applicable in wide range of areas with special emphasis on medicine. In present publication series of chitosan based hydrogels modified with gold nanoparticles were prepared. These materials were subsequently characterized by a number of physicochemical analysis concerning determination of cytotoxicity to epidermal cells. Based on these research it can be concluded that hydrogels containing small quantities of gold nanoparticles do not exhibit toxicity in relation to these cells. Furthermore, it can be said that addition of nanogold into hydrogel resulted in a decrease of its porosity as well as in a slight decrease of the sorption capacity of materials tested. Prepared polymers were characterized by biocompatibility in relation to simulated body fluid. Proposed hydrogels constitute an interesting type of materials that could be potentially considered for biomedical use.
- Record ID
- CUT711ff9a1c4444ab59ded8c4a5bc4211f
- Publication categories
- ;
- Author
- Journal series
- Journal of Polymer Research, ISSN 1022-9760, e-ISSN 1572-8935
- Issue year
- 2017
- Vol
- 24
- No
- 10
- Pages
- [1-7]
- Article number
- 153
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 6-7; Bibliografia (liczba pozycji) - 24; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 24, Iss. 10
- Keywords in English
- chitosan, hydrogels, nanogold, cytotoxicity, epidermal cells
- DOI
- DOI:10.1007/s10965-017-1315-3 Opening in a new tab
- URL
- https://link.springer.com/article/10.1007/s10965-017-1315-3#citeas Opening in a new tab
- Related project
- Zastosowanie Beetosanu do otrzymywania nowoczesnych biomedycznych matryc hydrożelowych. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- License
- Score (nominal)
- 30
- Publication indicators
- = 29
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT711ff9a1c4444ab59ded8c4a5bc4211f/
- URN
urn:pkr-prod:CUT711ff9a1c4444ab59ded8c4a5bc4211f
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.